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Inspiring Science

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Inspiring Science

Category Archives: Genetics

Correction: Plants micro-RNAs might not regulate animal genes

09 Tuesday Jul 2013

Posted by sedeer in Genetics, Humans, Mammals, Plants

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Tags

biology, digestion, DNA, Gene expression, GMO, Health, horizontal transfer, Human, MicroRNA, Mouse, nutrition, Popular science, RNA, science

Around a year ago I wrote about a study which showed that micro-RNAs from plants that were eaten could regulate genes in the animal that ate them.  It was an exciting and important finding.  The study claimed that the miRNAs survived passage through the digestive tracts of mice, got into their bloodstream and traveled to their liver, where they regulated genes involved in cholesterol metabolism.  This week I read a post on Virginia Hughes’ blog Only Human where she discusses several follow-up studies which haven’t been able to reproduce the original results.  That doesn’t necessarily mean the study was wrong, but it certainly raises doubts.  In her post, Virginia also links to a rebuttal letter she received from the author of the original study, so it looks like the debate is on!  I’ll try to keep an eye on the subject and report back about it as things develop, but in the meantime read Virginia’s excellent summary of the current state of affairs.  Showing that creatures can directly regulate genes in organisms of another kingdom of life would be a major finding, so I’m really glad that there’s debate about it.  That’s how science should work: we should try to repeat studies, remain critical and open-minded, and challenge each other.

The pan-genome of Emiliania huxleyi

28 Friday Jun 2013

Posted by sedeer in Genetics, Microbiology

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algae, biology, bloom, Ehux, Emiliania huxleyi, Genome, Popular science, science, Species, White Cliffs of Dover

Under certain conditions, Emiliania huxleyi can form massive blooms which can be detected by satellite remote sensing. What looks like clouds in the water, is in fact the reflected light from billions of coccoliths floating in the water-column. Landsat image from 24th July 1999, courtesy of Steve Groom, Plymouth Marine Laboratory. This bloom attracted considerable coverage in the UK media. (Photo credit: Wikipedia)Emiliania huxleyi has more going for it than just a beautiful name. Despite being only a few millionths of a millimeter in size — about a tenth of the thickness of a human hair — this unicellular alga has a major impact on our planet. Blooms of E. huxleyi, which can cover more than 100,000 square kilometres of ocean, are visible from space and affect the global climate; the concerted impact of all the cells in the bloom influences carbon and sulphur cycles and even changes how much light the Earth reflects. Under an electron microscope, E. huxleyi cells reveal their striking, alien beauty; encased in tiny plates called coccoliths, they look like strange spaceships or escape pods. E. huxleyi lives throughout the world’s oceans, from the warm tropics to the subarctic seas, and these plates underlie its remarkable impact on the planet’s climate and geology.
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The viruses that made us

29 Wednesday May 2013

Posted by sedeer in Development, Evolution, Genetics, Humans, Mammals

≈ 10 Comments

Tags

biology, DNA, evolution, Genome, horizontal gene transfer, Popular science, science, virus

Enterobacteria phage λ, Lambda phage-coliphage λ, José F. Vargas, http://elnefashu.deviantart.com/ (Photo credit: PHYLOMON)Viruses make their living by breaking into cells and using the machinery and energy in the cell to reproduce.  Once inside, some viruses immediately hijack the cell and make copies of themselves which burst out into the world to infect new cells.  Other viruses take a staid approach, though.  Instead of taking over the cell, they quietly slip a copy of their genes into its DNA.  When the cell divides, it copies the newly acquired viral genes along with the rest of its genome.  It’s a better deal for the virus, since all of the cell’s descendants will be carrying viral genes which can eventually come out of hiding to commandeer the cell and replicate.  A really lucky virus is one that finds itself inside an egg cell.  Getting into the DNA of a single cell means getting copied into all of its daughter cells, but getting into the DNA of an egg cell means getting copied into every cell in the organism that grows from the egg…and from there into all of the organism’s offspring.  Lucky viruses that succeed in pulling off that trick can still break out and cause trouble, but they can also become integrated into their host’s genome; instead of struggling to reproduce, they can then just kick back and enjoy the ride while we lumber along, making copies of them whenever we make new cells or have children. Continue reading →

An amazing critter with seven sexes!

29 Friday Mar 2013

Posted by sedeer in Genetics, Microbiology

≈ 8 Comments

Tags

biology, Mating type, Popular science, science, sex, Tetrahymena, Unicellular organism

The lovely Tetrahymena thermophila. (Photo credit: Wikipedia)If you’ve never heard of Tetrahymena thermophila, your world is about to get much stranger.  This little beauty, a single-celled creature that’s been at the heart of many major discoveries, has seven sexes that can mate with each other!  In a paper just published in PLoS Biology, a team of scientists have described the intricate dance of DNA editing and rearrangement which determines the sex of a new T. thermophila.

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What makes our intelligence heritable?

26 Tuesday Feb 2013

Posted by sedeer in Genetics, Humans

≈ 8 Comments

Tags

biology, G factor (psychometrics), Genetics, Genome-wide association study, GWAS, heritability, Human, intelligence, Intelligence quotient, People, Popular science, science, science and society

English: Thinking, bright idea.A study from the University of Edinburgh claims to have found the basis of our intelligence in thousands of genes scattered throughout our genome. Although the discovery was made possible by a new statistical method and modern sequencing technology, how the results are interpreted hinges upon a century-old debate about what intelligence is and how we measure it. Will we ever be able to measure something so indefinable or discover the genes behind it? Continue reading →

Sex and sociality: the genetics of being different

01 Friday Feb 2013

Posted by sedeer in Development, Genetics, Hymenoptera, Insects

≈ 7 Comments

Tags

Ant, Ant colony, ants, Chromosome, DNA, Fire ant, Gene, polygyny, Popular science, Queen ant, Red imported fire ant, science

Solenopsis invicta (Photo credit: AJC1)An international team of researchers studying fire ants have discovered the first “social chromosome”.  While this is obviously exciting to those of us who are fascinated by the advanced social organization of ants, the discovery also has broader implications.  The mechanism the researchers uncovered is similar to how sex is determined in many animals, creating the tantalizing possibility that it might be an example of a more general mechanism for evolving distinctly different complex behaviours. Continue reading →

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