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Inspiring Science

Tag Archives: DNA

The viruses that made us

29 Wednesday May 2013

Posted by sedeer in Development, Evolution, Genetics, Humans, Mammals

≈ 10 Comments

Tags

biology, DNA, evolution, Genome, horizontal gene transfer, Popular science, science, virus

Enterobacteria phage λ, Lambda phage-coliphage λ, José F. Vargas, http://elnefashu.deviantart.com/ (Photo credit: PHYLOMON)Viruses make their living by breaking into cells and using the machinery and energy in the cell to reproduce.  Once inside, some viruses immediately hijack the cell and make copies of themselves which burst out into the world to infect new cells.  Other viruses take a staid approach, though.  Instead of taking over the cell, they quietly slip a copy of their genes into its DNA.  When the cell divides, it copies the newly acquired viral genes along with the rest of its genome.  It’s a better deal for the virus, since all of the cell’s descendants will be carrying viral genes which can eventually come out of hiding to commandeer the cell and replicate.  A really lucky virus is one that finds itself inside an egg cell.  Getting into the DNA of a single cell means getting copied into all of its daughter cells, but getting into the DNA of an egg cell means getting copied into every cell in the organism that grows from the egg…and from there into all of the organism’s offspring.  Lucky viruses that succeed in pulling off that trick can still break out and cause trouble, but they can also become integrated into their host’s genome; instead of struggling to reproduce, they can then just kick back and enjoy the ride while we lumber along, making copies of them whenever we make new cells or have children. Continue reading →

Whose genome is it anyway?

21 Tuesday May 2013

Posted by sedeer in Discussions

≈ 19 Comments

Tags

Angelina Jolie, biology, DNA, Education, Full genome sequencing, Genetic testing, Genome, genomics, Genotyping, Health, Human, People, Popular science, relatedness, science, science and society, Science in Society

Angelina Jolie at the 2010 Comic Con in San Diego (Photo credit: Wikipedia)Fifteen years ago it was the stuff of science fiction.  Now, you can just swab your cheek, send it to a company and, for only a few hundred euros, have your DNA analyzed.  You’ll find out about your ancestry and your predisposition towards certain inherited diseases or conditions (from cancer and diabetes to myopia).  You’ll also learn if you’re a ‘carrier’ — that is, if you’re carrying a gene that won’t affect you but might affect your children.  You can even get information about more light-hearted issues like whether you’re likely to have fast- or slow-twitch muscles or your ability to taste certain bitter flavours.  The technology is pretty great, but it also raises some interesting questions which I thought would be worth discussing (especially since I really enjoyed our previous discussion). Continue reading →

New targets for HIV therapy

20 Wednesday Feb 2013

Posted by sedeer in Disease, Form, Humans

≈ 5 Comments

Tags

AIDS, biology, DNA, drugs, grid computing, HIV, Immune Disorders, Popular science, Protein, RNA, science

HIV (small green spheres) budding from a cultured cell (in blue). (Photo credit: CDC)In a pair of studies published last year, researchers across Europe used computer simulations to make major advances in our understanding of HIV. Taking advantage of distributed computing networks, they simulated key processes and molecular interactions in the life cycle of the virus, identifying new targets for drug therapy. Continue reading →

Sex and sociality: the genetics of being different

01 Friday Feb 2013

Posted by sedeer in Development, Genetics, Hymenoptera, Insects

≈ 7 Comments

Tags

Ant, Ant colony, ants, Chromosome, DNA, Fire ant, Gene, polygyny, Popular science, Queen ant, Red imported fire ant, science

Solenopsis invicta (Photo credit: AJC1)An international team of researchers studying fire ants have discovered the first “social chromosome”.  While this is obviously exciting to those of us who are fascinated by the advanced social organization of ants, the discovery also has broader implications.  The mechanism the researchers uncovered is similar to how sex is determined in many animals, creating the tantalizing possibility that it might be an example of a more general mechanism for evolving distinctly different complex behaviours. Continue reading →

From chimps to chickens: how a little DNA can make a lot of difference

06 Sunday Jan 2013

Posted by sedeer in Development, Evolution, Genetics

≈ 6 Comments

Tags

alternative splicing, animals, biology, DNA, Gene, Genome, mammal, Messenger RNA, Popular science, RNA sequencing, RNA splicing, science, Species, Transcriptome, vertebrate

A stretch of DNA (Image credit: Wikipedia)Humans and chimpanzees famously share more than 98% of their genome and yet the two species look and behave quite differently.  This apparent paradox stretches well beyond our little corner of the tree of life; we share more than half our genes with chickens and those we share are 75% identical.  Two studies published together in the December issue of Science tackled this perplexing discrepancy by showing that there may be more to a genome than meets the eye. Continue reading →

How short can genes get?

20 Saturday Oct 2012

Posted by sedeer in Form, Genetics

≈ 2 Comments

Tags

biology, DNA, Gene, Gene expression, genetic regulation, Polyadenylation, Popular science, Regulation of gene expression, RNA, RNA processing, science, terminator

Static thumb frame of Animation of the structure of a section of DNA. The bases lie horizontally between the two spiraling strands. (Image credit: Wikipedia)A team of scientists at Aarhus University in Denmark reported a remarkable discovery in this month’s issue of the journal Genes & Development.  Genetic regulation is a complex and intricate affair carefully orchestrated by an array of proteins and other factors.  While the basics are well understood, the researchers discovered that the length of the gene itself may also have a role, adding another twist to the already complex and intricate story of genetic regulation.

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